And, so today, I get to design, not the science part, but I get to design how we take the science into that innovation ecosystem that we're trying to build. For transplant patients, they feel good because they're taking their medication, right. The Terasaki Institute for Biomedical Innovation is an independentnon-prot organization and usesan integrative approach to inno-vate personalized health. I've had one boss my entire life, and that was Paul Terasaki. It just opened up a whole new kind of area for me that I wasn't aware of. To capture TIBIs narrative, I reached out to CEO Ali Khademhosseini, President Stewart Han, Chief Innovation Officer Maurizio Vecchione. Powered By: RecootyRecooty We like to think about the technologies that we're developing as being platforms. Can you give some of that legacy history from your company One Lambda to Terasaki Institute? But to answer your initial question, as I exited, Global Good, and the Gates ecosystem, I was looking for a place that could apply the learned lessons of that sort of translational innovation. But understand that for the science to actually have an impact, you can't just limit it to, getting the cover of Nature, or other scientific journals. Developing individualized solutions and prototyping tangible What was really exciting, because we're relatively young and new, is certainly as in the incarnation that I've described to you, which is really sort of the successor to Paul Terasaki, his original vision, where he really was focused on the transplantation problem. I'm just happy that I can really try to carry on Dr. Terasakis legacy. I'll give you an example. Okay, for whatever disease I have, but that's not really it. If you engaged with him, he was always there willing to give his advice and be a fantastic mentor. Personalized nutrition; come up with alternatives for your nutrition. That's right. As there is overlap between the three interviews, with Stewart, I focus on the journey that led to the founding of TIBI. It's not just the financial return. You're growing cells, right? Agriculture is responsible for (according to some estimates) 15% of greenhouse gases in the world. And so, for example, they can react to the chemistry in the body. You're talking about a humble, shy individual, but brilliant and transformational in terms of his thinking and innovative capability. If you think about the ecosystem of biomedical innovation, and you think about the complexities that a lot of companies face, to license out of universities and dealing with the patchwork and complexities of IPs, as well creating structures that allow those companies to take risk on new technologies, without necessarily getting into a quagmire of relationship. Terasaki Institute For Biomedical Innovation was ranked 6808 among all visa sponsors. And then at the end of the day, we put all of these in controlled environments that we can flow liquids through so interfaces or work with micro fluidics community. Chronic rejection is really the main enemy of transplanted organ. Shortly after that, I got contacted by a number of companies that were interested in my consulting services. That means it's an ideal collection item for matrices in the body that haven't been studied before, such as interest tissue fluid. He started looking at all his data and trying to correlate cancer outcome with the HLA
data that he had established, or that he was looking at. If you think about the regulatory risk and the timelines that are associated with some of these projects, that's a significant risk. When you look at and you want them to work in spaces that are wet, like have blood around it, or things like that, so it's not trivial; the normal kinds of materials that you use to stick two pieces of plastic together don't really work in those environments. I have two. And then you have to commercialize, which is almost impossible for a lot in the science community. And, if any of your viewers ever saw the relatively dark, so we'll use this as an example of application, TV show Westworld, where essentially robots were built using tissue engineering, and there was 3D bioprinting involved. Terasaki Foundation Laboratory. And that's language that should be welcomed to anybody in your audience, who is looking to essentially input into the product pipeline. Let's see how we can work together. For example, when there are defects in the blood vessels like aneurysms or what they call VMs , which are malformations in the blood vessels. And there is not a value to do incremental work. Initial tests using MOS from a small cohort of metastatic colorectal cancer patients were screened against a panel of therapeutic drug candidates. One of those initiatives that addresses both planetary health as well as nutrition. But in virtually everything that we do, there is this opportunity to really use data sciences. 6/23/2023 08:25:13 pm. So that's the kind of stuff that we think we can enable, by doing a lot of things that we talked about, again; it's convergence, data science, plus . Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064 USA. And, there's lots of opportunities, I think, to accelerate working together. Biomaterials also allow you to create constructs, like moving away from injections into, say micro needles. You talk about the science part. Prior to joining, Ali was Levi Knight Professor of Bioengineering, Chemical Engineering, and Radiology at the University of California-Los Angeles (UCLA). That is, it's passive. I started with the Terasaki Institute in 2018. 11377 Bunche Hall. The Terasaki Institute for Biomedical Innovation is an independent non-profit organization and uses an integrative approach to innovate personalized health. You can work on a big problem, but typically the same amount of effort. One of the areas that he's focusing on, which happens to leave a very big footprint on the planetary health situation is with agriculture. You're taking stem cells and coaxing them; you're building some kind of structure or scaffolding perhaps of some sort. And it's I think, the reason why tech transfer from universities, the old-fashioned way typically has been that successful; has been successful, but not that successful. These include IPhone / Mobile Compatible , SPF , and SSL by Default. So, you know, for example, we have an ongoing program for breast cancer on a chip, including some of the breast cancers that are most difficult, , we're starting to explore metastasis on a chip. And these are just examples of the kinds of things you can do. I haven't really talked about that integration much. So, he had a lot of unfinished business, as do all great researchers. I thought I had done everything. And you get the scenario where you get this amazing, globally changing work, but you can scale it to any part of the planet as well. There are very few approaches to solve them. But there's other components. Interviews appear with the non-profit IEEE TEMS. I met him. As a student coming into the laboratory, you really wanted to excel at what you were doing. It can be injected into the body to treat wounds on the heart or treat wounds on the liver. The Terasaki Institute for Biomedical Innovation is an independent non-profit organization and uses an integrative approach to innovate personalized health. In addition to wanting to continue his work and research, he had always wanted to delve into looking at the intersection of cancer and transplantation. Los Angeles, California, 90024, United States And by the way, when you have these different organs, you can also integrate them. Personalized medicine really is a way to target disease, at the stage, and genetic composition, that it's at. For example, some of the things we're trying to do is make materials that are really sticky. It's developing meat in the laboratory. Are there three locations for TIBI? Right now, again, pharma still uses that same kind of platforms and technologies that they've developed 50 years ago, to do their drug development and drug discovery process. We discuss engagements with institutions, corporations, and incubation of startups.>. The fact that you have already built a system so that you can span the entire range is just remarkable. Search for more papers by this author. In the interview with Maurizio, this is discussed from the viewpoint of the Chief Innovation Officer.>. They definitely would be interested in your work; replicas of real meat products, and, of course, addresses climate and energy, and so on. And I think these are also very short-term projects for us. So, by being able to take, let's say, a piece of a few skin cells, and then be able to turn those cells into primitive stem cells that can make the different tissues of that individual, then we can also really have predictiveness. We definitely have a few different projects that are, I think, are really exciting. Maurizio Vecchione is also jointly serving as the CEO of Washington Global Health Alliance, a non-profit organization that plays a pivotal role in fostering collaboration among leading global health institutions. It is the Terasaki Institute's third. I've been doing tissue engineering for 20 years. And we've been so successful using and applying some of our tissue engineering, that we can take complex organs or complex tissues, and they can operate like the real thing. What are some of the big ideas that you want to tackle? Often, they're highly biocompatible. All those steps beyond the R&D are very difficult. Job Title. I represent, I think, a group of people that are coming together at the Terasaki Institute, which you could qualify or classify as academic entrepreneurs, we all are scientists first. All Rights Reserved. And in part it is because we're using high throughput processes that are basically saying, let's take a bunch of molecules, let's throw them at an indication. Okay, statistically, that's true. I started working for him fresh out of college. Terasaki Institute for Biomedical Innovation:: Our Mission:: To invent and foster practical solutions that restores or enhance the health of individuals. And we think of microneedle using hydrogel materials are actually going to be the first way to collect in relatively large volume interstitial fluid, which opens up a whole new area of diagnostic capabilities, probably centering on proteomics that hasn't been exploited before. These are all bringing what we call convergent science, bringing together areas of science that are traditionally not been interacting with each other and putting them together to solve problems. And they actually have done clinical trials and have demonstrated that this works and how now have a company that recently raised its series A to be able to translate these kinds of technologies into a real-world application. Terasaki Institute, Amazon, Harvard, MIT - Cited by 112,752 - bioengineering - drug delivery - biomaterials - tissue engineering - regenerative medicine . So maybe I'll stop there, but I think those are some of the revolutions that we feel are occurring that we're writing. That turnaround to getting real world application is much less, whereas when you have cells and things you really have long regulatory approval. His robots create new opportunities in surgical suturing and vision-based robotic manipulation. 1018 Westwood Blvd . And by the time we're ready to do a spin out or a corporate partnership, what we have is solutions to big problems that have actually be reasonably de-risked and now will become a profile that makes them investable from a private capital perspective. The Institute draws on its scientic, entre-preneurial, and engineering skill set to transform ideas into clinicallyapplicable technologies. From 2014 until 2020, he was the executive vice president for Global Good and Research at Intellectual Ventures (IV) where he oversaw collaboration with Bill Gates to invent and deploy technology to address some of humanity's most daunting challenges. And the other 80% don't not only have no effect on, they may actually have side effects on. For example, he has developed numerous techniques in controlling the behavior of patient-derived cells to engineer artificial tissues and cell-based therapies. To continue his studies, working with the folks at UCLA, because he was a tremendous Bruin , he was a tremendous alumni and supporter of UCLA. WOODLAND HILLS, Calif., April 27, 2023 /PRNewswire/ -- The Terasaki . He felt that without UCLA, he wouldn't have been in the position that he had. He always wanted to give back to the university. What kind of projects we want to fund and what kind of outcomes we're looking for from those projects. This became the flagship of the transplant diagnostic industry. For example, we have cardiac models, where the organs on a chip actually begins to pulsate, the way the real heart does, and we're now working on, for example, neural models where we have brains on a chip, and more importantly, we're able to start building disease on a chip. Once I did get to meet him, and really increase my interaction with him, you really tried to engage with him; it wasn't any type of hierarchy thing with him. Bill from his prior work as CEO of BC Transplant, is intimately familiar with and utilized the pioneering work and leadership of Dr. Paul Terasaki and Arushi speaks of the utility of the solutions offered by the present day Terasaki Institute (TIBI) in SCI. So, to me, the reason why personalized medicine is important, is because as disease gets more complex, we're going to have to get very targeted in the delivery, in what our drugs and devices do in order to be effectivewhen you think about cancer therapies, for example, it's all about targeting, and it's all about stage of the cancer, and it's all about the heterogeneity of the cancer, as it moves across its phases, and its patients. He invited a few of us to come into his company. And in order to scale those technologies up, he took the courageous step of starting a company. | The Terasaki Institute for Biomedical Innovation envisions a world where personalized medicine is . Terasaki Institute for Biomedical Innovation Headquarter Location. I want to start by triggering on a comment you made, which has big problems. So, you're focusing on the big problem, big impact, and scalable. And that is very true. We've been developing new classes of materials that you can put in those regions; you can deliver these materials through the catheter, they're like, to somebody like a toothpaste, you can kind of deliver them. Dr. Terasaki established the kidney transplant registry, which would eventually become the United Network for Organ Sharing registry. I fundamentally been thinking that the ultimate impact of the kinds of stuff that we've been doing is not really going to be in transplantation. There are other impacts like ranch land, and water, the effect on our water tables. It's also a hardcore business strategy to develop disruptive Unicorns of tomorrow, that have the potential to unleash the next trillion-dollar companies. Definitely so. One of the faculty that we recently hired at the Institute in the US recently came to us from Duke University, his name is Xiling Shen, and what he's done is quite incredible, because he actually takes tumor cells and forms them into these organoidsbeen able to then test different drugs, different chemotherapeutics on these tumor cells, and then see which drug works on which person's tumor. He had retired from UCLA in 1999. I just was blown away by his approach to addressing some of the problems. He saw something in you and that's your brilliance as well. We're in constant growth mode. He was just a shy, soft-spoken individual. School of Engineering, Westlake University, Hangzhou, Zhejiang Province, 310024 China. You know, R&D rich innovation. He is really diversified the revenue stream here at the Institute. That type of technology and as you think about regenerative medicine, as you think about being able to 3D print, things that will go into your body and they are biocompatible, and they mimic original tissue, there's all sorts of medical applications that are very disruptive, that are emerging from that area. Throughout his career, Maurizio has blended scientific research and innovation with impact investing delivering a double bottom lines of investor return and social impact. He was the Founding Director of the Center for Minimally Invasive Therapeutics at UCLA. I did do some projects for him. That being said, I was still at One Lambda till about 2014. Tel (310) 825-4500 Fax (310) 206-3555. But he did take me under his wing. He's always working on possible collaboration with industry. They have adopted a model for working with and accelerating startups. And then being able to scale it to those relationship networks, to the different models, and even the incubation capability that you have. These are smart materials that you can deliver inside the body and be able to use the body's innate ability to do things to basically regenerate or induce, you know, tumor cell or things like that, with that, and you can actually integrate these sorts of materials with immune therapies. That's the end using cells and materials to, and techniques like 3D printing to actually create living tissues. We can't quite announce the specifics of it yet. It's just not sustainable how much meat that they will require in the next 10 to 20 years. Terasaki Institute For Biomedical Innovation has filed 33 labor condition applications for H1B visa and 0 labor certifications for green card from fiscal year 2020 to 2022. Dr. Khademhosseini's interdisciplinary research has been recognized by over 60 major national and international awards. There's a lot of work that has been done in taking normal electronics, being able to put them on flexible substrates, substrates that are stretchable, and at the same time, be able to manufacture these at low enough prices, and with the integrated batteries and all that stuff. He wanted this institute to have an affiliation with UCLA. It's the same amount of effort. This is a lesson I actually learned firsthand, working with Bill, that, there is a connection between high impact and ultimately high shareholder return and scalability and performance and this is a place where business profits and the metrics associated with that.
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