age classification who pdf

1987;59(9):161725. CAS The WHO World Standard population has fewer children and notably more adults aged 70 and above than the world standard. 2015;17(6):77683. The heatmap of glioma with EGFR negative expression. Cancer. while another population-based glioblastoma study with five age groups (<50years, 5059years, 6069years, 7079years, and>80years) showed that the OS of young patients (<50years) was significantly longer than that for elderly patients (>50years) (median 8.8months vs 4.1months, p<0.001) [20]. B: Heatmap of youth group. In total, we collected 10,257 orthopantomograms . 129:635642. ROC curve of the sensitivity and specificity for diagnosing WHO IV glioma (a) and high grade glioma (b). Diffuse astrocytoma, diffuse midline glioma, H3K27M-mutant glioma, oligodendroglioma, oligoastrocytoma and myxopapillary ependymoma commonly occurred in youth group. Gender, age, anatomic location of the tumor, size of tumor and molecular markers are simple and objective parameters that can be collected easily in clinical practice or clinical studies on patients with glioma. Background Age is associated with the prognosis of glioma patients, but there is no uniform standard of age-group classification to evaluate the prognosis of glioma patients. 2003;62(11):111828. Proceedings of the 2019 on International Conference on Multimedia Retrieval 2019. For more information on why we use single ages, refer to 2000 UNSD classifications. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. According to the results of age-specific osteoporosis tests conducted in Australia, age-related osteoporosis was found in 20% of patients aged 50 to 59 years, 46% of patients aged 60 to 69 years, 59% of those aged 70 to 79 years, and 69% of patients aged over 80 years . Increasing translational studies have significantly advanced the understanding of glioma pathogenesis and have identified several prognostic factors. 6 Jun 2018. A multilayer perceptron (MLP) is typically made of multiple fully connected layers with nonlinear activation functions. https://doi.org/10.1016/j.ccr.2009.12.020. c Histological distribution by 4863years old group, and d Histological distribution by 64years old group. https://doi.org/10.1016/S0140-6736(01)05379-X, Article Google Scholar, Hagen M, Schmidt S, Schulz R, Vieth V, Ottow C, Olze A, Pfeiffer H, Schmeling A (2020) Forensic age assessment of living adolescents and young adults at the Institute of Legal Medicine, Munster, from 2009 to 2018. Simultaneously running multiple modules is a key requirement for a smart multimedia system for facial applications including face recognition, facial expression understanding, and gender identification. f The diagnosed age boxplot figure of oligodendroglioma and anaplastic oligodendroglioma. C: Heatmap of middle-age group. U.S. Standard Population vs. Standard Million. An age classification utilizing Support Vector Machine (SVM) classifies age in groups. J Natl Cancer Inst. For more information on why we use single ages, refer to 2000 U.S. Standard Population vs. Standard Million. Ependymoma gradually decreased in the younger age groups (Fig. It is recommended that age be calculated from date of birth and the study enrollment date. It. International Classification of Functioning, Disability and Health: Describes functional health status and social impact (bio-psycho-social model). Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. The clinical practice patterns show that with increasing age, the application of surgical resection, radiotherapy and chemotherapy decreases [29,30,31]. Google Scholar. https://doi.org/10.1054/bjoc.2000.1580. The results revealed great heterogeneity across the four age groups (Supplementary Figure S4, S5, S6, S7, S8, S9, S10, S11, Supplementary Table S4-S5). To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. https://doi.org/10.1007/s00330-019-06167-y, He T, Guo J, Chen N, Xu X, Wang Z, Fu K, Liu L, Yi Z (2020) MediMLP: using Grad-CAM to extract crucial variables for lung cancer postoperative complication prediction. The median age of patients with anaplastic oligoastrocytoma is 42.5years. Cumulative age distribution and T test of the average age at diagnosis of different types of glioma. Provided by the Springer Nature SharedIt content-sharing initiative, https://doi.org/10.1007/s00414-021-02542-x, access via A: Heatmap of pediatric group. Neuro-Oncology. Therefore, for patients diagnosed with glioma by imaging examination and auxiliary examination, it is necessary to consider the age of the patients to perform personalized treatment for better outcomes. Tumors in the supratentorial areas of the brain (cerebral hemispheres and midline structures above the tentorium) were most frequent in adults, while subtentorial (brainstem and cerebellum) tumors were more common in young children than in adolescents and adults [10]. A study indicated that the prognostic effects of P53, 1p, and CDKN2A/p16 alterations are dependent on patient age [39]. Automatic age and gender classification based on unconstrained images has become essential techniques on mobile devices. The heatmap of glioma derived from ependymal cells differentiation. A: Heatmap of pediatric group. Int J Legal Med 124:183186. https://doi.org/10.1093/jnci/93.16.1246. In addition, we compared the average age at diagnosis of various pathological subtypes of glioma. At double the age of previous winners, Rose Wiley . CAS 2001;56(1):438. Does age matter? World report on ageing and health. Fuller CE, Schmidt RE, Roth KA, Burger PC, Scheithauer BW, Banerjee R, et al. ICD Implementation. In addition, the prognosis of glioma is particularly severe in older adults [26, 28]. 12 papers with code 2e). https://doi.org/10.1056/NEJMoa043331. They may also be referred to as teenagers depending on the context.) The probability of high-grade glioma or WHO IV grade glioma in the age group 64years was greater than that of the age group 4864years old. c Heatmap of middle-age group. However the health organization had done a new research recently, according to average health quality and life expectancy, and defined a new criterion that divides human age as follows: By 2050, one in four. Based on this age group classification, we further analyzed the characteristics of WHO grade, tumor size, tumor histology, and anatomical location among the four age groups. https://doi.org/10.1158/0008-5472.CAN-04-1337. Methods 166:421. World health organization age classification 2020. Our research indicated that the classification criteria based on the age for glioma patients were 014years old (pediatric group), 1547years old (youth group), 4863years old (middle-aged group) and64years old (elderly group). Deep learning techniques have been applied for age estimation recently but lacking performance comparison between manual and machine learning methods based on a large sample of dental orthopantomograms (OPGs). dpressel/rude-carnie Prognostic factors influencing clinical outcomes of glioblastoma multiforme. This paper proposes a fusion-based gender recognition method which uses facial images as input. The design and data collection of this study were supported by the Guangdong Science and Technology Department (2016A040403053). Privacy Critical revision for important intellectual content: ZYL, RWY, KSL YWL, GZY, ZYL, JLG, ZZ, JXP, STQ, and GLH. 2012;482(7384):22631. PubMed Four age groups, including babies, young adults, middle-aged adults, and old adults, are used in the. https://doi.org/10.1007/s00414-021-02542-x, DOI: https://doi.org/10.1007/s00414-021-02542-x. 2010;12(2):15363. Detailed information for this cohort of glioma patients is recorded in Supplementary Table S1. The 2019 revision, by 2050, one in six people in the world will be over age 65 (16%), up from one in 11 in 2019 (9%). However, in the youth and middle-age groups, the frontal lobe accounted for the largest proportion (Supplementary Table S3, p=0.000). Conception and design of the work: GLH, STQ, ZYL, and RWY. The cut-off of the model with the minimum AIC value was calculated by the same method described above. vi World Health Statistics 2022 - Monitoring health for the SDGs Introduction The World health statistics report is the World Health Organization's (WHO) annual compilation of health and health-related indicators for its 194 Member States, which has been published since 2005. Accurate age classification using manual method and deep convolutional neural network based on orthopantomogram images. Central Brain Tumor Registry of the United States. Common health conditions associated with ageing. https://doi.org/10.1080/20961790.2018.1526251, Yin W , Kann K , Yu M, Schutze H (2017) Comparative study of CNN and RNN for natural language processing. 23 Jul 2019. Age estimation is an important challenge in many fields, including immigrant identification, legal requirements, and clinical treatments. Moreover, a larger tumor burden might cause a higher risk of functional deficits, including motor dysfunction, impaired communication ability or decline in neurocognitive function [2]. 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong, China, Zhiying Lin,Runwei Yang,Kaishu Li,Guozhong Yi,Zhiyong Li,Jinglin Guo,Zhou Zhang,Peng Junxiang,Yawei Liu,Songtao Qi&Guanglong Huang, The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China, Nanfang Glioma Center, Guangzhou, 510515, Guangdong, China, Guozhong Yi,Zhiyong Li,Peng Junxiang,Songtao Qi&Guanglong Huang, You can also search for this author in https://doi.org/10.1016/j.joen.2019.03.016, Lee JH, Kim DH, Jeong SN, Choi SH (2018) Diagnosis and prediction of periodontally compromised teeth using a deep learning-based convolutional neural network algorithm. De-differentiation of papillary thyroid carcinoma into squamous cell carcinoma in an elderly patient: A case report. a Histological distribution by 014years old group. Children below age 2 should be considered at their corrected age if they were premature. Brain Res Bull. PubMed For this purpose, we conducted a retrospective study collecting clinical data from 1502 patients with histologically proven gliomas in Nanfang Hospital between 2000 and 2018. https://doi.org/10.1002/1097-0142(19870501)59:9<1617::aid-cncr2820590916>3.0.co;2-x. The ratio of males to females was 1.4:1. https://doi.org/10.1007/s00414-008-0279-6, Olze A, Solheim T, Schulz R, Kupfer M, Pfeiffer H, Schmeling A (2010) Assessment of the radiographic visibility of the periodontal ligament in the lower third molars for the purpose of forensic age estimation in living individuals. First, dummy variables were created by age groups of 0-I years old and I-47years old (I: any age between 2 and 46). 1b). 1a, p <0.05). 4 datasets. A person is now considered young before 44 years of age. All data generated and analysed in this study are included in this article and supplementary materials. Histological distribution by Age groups. The General 1 Secretary-General's Report to the General Assembly, A/36/215, 1981 Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: a population-based study. According to the discriminant classification of whether the pathological diagnosis of the patients was WHO grade IV or not, the prediction probability was taken as the discriminant dividing point, and the total judgment rate was 74.0% (h). https://doi.org/10.1056/NEJMoa1611977. The established dummy variables were considered as independent variables, and a logistic regression model was set up according to whether glioma patients were high grade glioma or WHO IV grade glioma. 2h). Usinskiene J, Ulyte A, Bjornerud A, Venius J, Katsaros VK, Rynkeviciene R, et al. Pearsons chi-square test was performed to compare the categorical data. Republic of korea situation daily weekly As the lead health authority within the united nations (un) system, we help ensure the safety of the air we. g Cumulative age distribution of Oligoastrocytoma and anaplastic oligoastrocytoma, the median ages of patients with oligoastrocytoma are 34.0years. Life expectancy at age 60 years is also greater for women than men: 21.9 versus 19.0 years. Cumulative age distribution and T test of the average age at diagnosis of glioma. The purpose of the system is to assess and communicate a patient's pre-anesthesia medical co-morbidities. By 2050, the world's population of people age 60 and older is expected to total 2 billion, up from 900 million in 2015, according to the World Health Organization. The pathological diagnosis included histological classification, WHO grade, and molecular expression. By using this website, you agree to our Lin, Z., Yang, R., Li, K. et al. Google Scholar. 1c and d, 43.0 vs 35.0years, respectively, p<0.05). Int J Legal Med 135:365373. Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. J Forensic Sci 54:651657. https://doi.org/10.1158/1055-9965.EPI-14-0275. In particular, glioblastoma (GBM, WHO grade IV) is the most common malignant tumor of the CNS, accounting for 45.2% of primary malignant the CNS tumors, and 54.0% of all gliomas [5]. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. https://doi.org/10.1016/j.forsciint.2017.12.043, Lee JH, Han SS, Kim YH, Lee C, Kim I (2019) Application of a fully deep convolutional neural network to the automation of tooth segmentation on panoramic radiographs. Epidemiologic and molecular prognostic review of glioblastoma. Patients aged 64years old were predisposed to gliomas of astrocyte differentiation. e Cumulative age distribution of Oligodendroglioma and anaplastic oligodendroglioma, most of oligodendroglioma and anaplastic oligodendroglioma arise in adults, with peak incidence in patients aged 3050years. Nat Rev Clin Oncol. Cookies policy. N Engl J Med. The proportion of positive expression of epithelial membrane antigen (EMA), vascular endothelial growth factor (VEGF) and O-6-methylguanine-DNA methyltransferase (MGMT) were maximal in the pediatric group, while the proportion of positive expression of neuronal nuclei (NeuN) and epidermal growth factor receptor (EGFR) were highest in the middle-age group (Fig. Therefore, for patients diagnosed with glioma, age should be taken into consideration to perform personalized treatment for a better outcome. 2009;122(11):12459. Income Level. The proportion of tumors with sizes of 04cm decreased with age; however, the proportion of tumors with sizes ranging from 4 to 6cm was larger in older groups (Supplementary Table S2, p=0.018). E: Heatmap of middle-age group. Representative genes are shown for each subtype. ivclab/CPG 2020GXLH-Y-008. Definition Age categorization is the process of categorizingothers or the self as belonging to a particular agegroup. The world health organization defines health as the complete physical, mental, and social functioning of a person and not merely the absence of disease. Reference Classifications International Statistical Classification of Diseases and related health problems: Diagnoses, injuries, findings, primary care. Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Clinical and molecular characteristics of the patients with gliomas classified by age groups. d Heatmap of elderly group. 2008;108(4):6428. D: Heatmap of elderly group. Between 2000 and 2016, global life expectancy at birth, for both sexes combined, increased by 5.5 years, from 66.5 to 72.0 years. The classification system alone does not predict the perioperative risks, but used with . vi WORLD HEALTH STATISTICS 22 INTRODUCTION T he World health statistics 2020 report is the latest annual compilation of health statistics for 194 Member States. 2005;75(2):18993. The authors declare that they have no competing interests. 135:665675. The World (WHO 2000-2025) Standards database is provided for 18 and 19 age groups, as well as single ages. https://doi.org/10.1016/j.ymeth.2019.04.008, Redmon J, Divvala S, Girshick R, Farhadi A (2016) You only look once: unified, Real-time object detection. J Periodontal Implant Sci 48:114123. BMC Cancer. J Forensic Sci 38:379390, Cameriere R, Ferrante L, De Angelis D, Scarpino F, Galli F (2008) The comparison between measurement of open apices of third molars and Demirjian stages to test chronological age of over 18 year olds in living subjects. https://doi.org/10.5051/jpis.2018.48.2.114, Article World health organization (who) scale for dehydration it is important to determine the degree of dehydration in order to select the appropriate plan to treat or prevent dehydration. In this cohort, when analyzing the average age at diagnosis of different IDH1 phenotypes by using the whole cohort, no significant differences were observed (Supplementary Figure S1B and D); however, IDH-wt GBM was diagnosed at an older age than that of individuals diagnosed with IDH-mut GBM (Supplementary Figure S1A and C, 49.3 vs 43.2, respectively, p<0.05). de Robles P, Fiest KM, Frolkis AD, Pringsheim T, Atta C, St Germaine-Smith C, et al. Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish Neuro-oncology registry. 2004;64(19):68929. Terms and Conditions, ( Image credit: Multi-Expert Gender Classification on Age Group by Integrating Deep Neural Networks ) Benchmarks Add a Result https://doi.org/10.1097/MD.0000000000019892. https://doi.org/10.1007/s11060-017-2607-5. NeurIPS 2019. 5). ivclab/PAE All pathological information was collected from the hospital medical records system. In addition to the marked heterogeneity of tumor size and histopathology, the heterogeneity of the molecular characteristics of tumors is becoming increasingly important and is reported in several studies. The model with the smallest AIC value was regarded as the best model. J Neuropathol Exp Neurol. F: Heatmap of elderly group. These contradictory conclusions could be partly explained by the difference in age classification criteria between different studies.
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