In the meantime, to ensure continued support, we are displaying the site without styles Selenium. 34, e499e510 (2011). All the other authors declare no competing interests. Am. Brandlistuen, R. E., Ystrom, E., Nulman, I., Koren, G. & Nordeng, H. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. Google Scholar. However, a particular obstacle is the difficulty in translating human outcomes, such as ADHD and ASD, to behaviour in an animal model. Neurotoxicol. PubMed Central Pregnant women should minimize risk by using the lowest effective APAP dose for the shortest possible time. 18, 233239 (1992). The cold and flu are caused by different viruses, but they often share common symptoms, which can make it difficult for people to tell the difference between the two. Allegaert, K. & van den Anker, J. In Texas, a rare program offers hope for some of the most vulnerable women and babies. Mller, D. et al. Instead, get the drug to treat the specific symptom you're experiencing. Gould, G. G. et al. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Am. Biol. Reel, J. R., Lawton, A. D. & Lamb, J. C. Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol. 101, 125147 (2018). Sass L, Urhoj SK, Kjrgaard J, Dreier JW, Strandberg-Larsen K, Nybo Andersen AM. Some liquid forms . Expect any skin that darkened during pregnancy such as dark patches on your face to slowly fade as well. Black, E. et al. Hoffman, J. F., Wright, C. L. & McCarthy, M. M. A critical period in Purkinje cell development is mediated by local estradiol synthesis, disrupted by inflammation, and has enduring consequences only for males. Liew, Z., Ritz, B., Rebordosa, C., Lee, P. C. & Olsen, J. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. Childs Nerv. A stuffy nose may feel even more congested than normal as the mucus membranes may already be a bit swollen due to hormonal changes during pregnancy. Croen, L. A. et al. 64, 562568 (2007). PLoS ONE 15, e0242773 (2020). It is sometimes used in inhalers for decongestion. Human epidemiological studies on APAP use in pregnancy should be designed to control for genetic factors. Vicks for relief of hemorrhoids is a controversial remedy. Brucato, M. et al. Bertoldi, A. D. et al. Its paraben free, sulfate free, mineral oil free, petrolatum free, formaldehyde free and cruelty free but full of plant extracts and antioxidants. In people who experience migraine headache, including women of reproductive age, studies show that migraine days can be decreased by reducing use of analgesics, including APAP43,44. Endocr. Any cold remedy containing alcohol, including Benadryl and, Codeine, a narcotic drug that may cause fetal respiratory depression. We comply with the HONcode standard for trustworthy health information. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe. Most studies, but not all33,34, have suggested that antipyretics such as APAP can reduce this risk32. Baker, B. H. et al. J. There are many safe options but also some that should be avoided either throughout pregnancy or in specific trimesters. 45, 19871996 (2016). Reprod. 3rd edn, p373 (Jones and Bartlett, 2014). J. Obstet. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. Levy, G., Garrettson, L. K. & Soda, D. M. Letter: evidence of placental transfer of acetaminophen. Molecules 26, 1845 (2021). True Botanicals website features each products full ingredient list full of natural substances like turmeric, yucca extract, jojoba oil, and things that are fun to (try to) say, like persea gratissima and zingiber officinale. One reviewer called it a dream come true!. Robin Elise Weiss, PhD, MPH is a professor, author, childbirth and postpartum educator, certified doula, and lactation counselor. Association of cord plasma biomarkers of in utero acetaminophen exposure with risk of attention-deficit/hyperactivity disorder and autism spectrum disorder in childhood. PLoS ONE 9, e108210 (2014). Randomized controlled trial of the effect of regular paracetamol on influenza infection. Many people use this as a second step to another cleanser, ensuring their face is as clean as possible before heading to bed or to work in the morning. That being said there are clean cleansers with the right essential oils that will do no harm to mother and baby. Doseresponse has been investigated in 19 studies112,113,114,116,117,118,119,120,121,122,124,127,128,129,130,133,136,137,138 and of these, 16 studies112,114,116,117,118,119,120,121,122,124,127,129,130,133,136,137 identified a doseresponse association, whereby increased duration of exposure was associated with increased risk. Even if youre a conscious beauty user and youve nixed the most offensive, toxic ingredients, strange things are happening to your skin now that youre pregnant (same with your hair, your vision you get it). Reprod. Menthol topical side effects. 45, 20092017 (2016). Liew, Z. et al. a feeling of throat tightness. 100, 8189 (2015). Commun. Epidemiol. J. Appl. Maternal biomarkers of acetaminophen use and offspring attention deficit hyperactivity disorder. Can I Take Cold Medicine While Breastfeeding? Medically reviewed by Drugs.com. Front. Hepatology 42, 13641372 (2005). Moreover, exposure of ex vivo adult testes to APAP has similarly shown a negative effect on testosterone production103. Our Fact Sheets are meant for general information purposes and should not replace the advice of your healthcare provider. We support this statement, which is consistent with our recommendations163. 198, 178.e1178.e7 (2008). Petroleum jelly: Safe for a dry nose? 866.626.6847, Media Inquiries https://www.knowyourdose.org/the-acetaminophen-awareness-coalition/. Get what matters in translational research, free to your inbox weekly. Toxicol. Community Nurs. 34, 267277 (2020). Many safer ingredients exist that can be used for vulnerable times (like pregnancy). Confounding by indication for use was controlled for in nine studies24,89,90,93,94,95,97,101,102. Medications and More during pregnancy and breastfeeding. 619.368.3259 Heres some good news to make your pregnancy skincare shopping easier (easier ANYTHING is great when youre expecting! We suggest specific actions to implement these recommendations. The endocannabinoid system is a complex network of lipid signalling pathways that have an important role in the developing nervous system160. Google Scholar. David, A. et al. oral discomfort (such as canker sores) aches and pains. Your skin is bouncing back and forth between dry, super dry, oily, super oily, and some insane combo that can not be controlled. J. Psychiatr. Vlenterie, R. et al. To put it in perspective, a typical cough drop contains between 5 and 10 mg of menthol. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Fever in pregnancy and the risk of congenital malformations: a cohort study. The natural scents are so relaxing. Psychiatry 25, 29702978 (2020). Worldwide, more than 50% of pregnant women are estimated to use APAP18,20,21. J. Mol. Mol. However, depending on the medication and dosage taken, there may be cause for concern. The EMA Pharmacovigilance Risk Assessment Committee should review the most recent research and issue an updated Drug Safety Communication10, including both epidemiological and experimental evidence. Foetal oestrogens and autism. Epidemiol. 2, CD013273 (2019). Allergy 45, 108113 (2015). Schultz, S., Gould, G. G., Antonucci, N., Brigida, A. L. & Siniscalco, D. Endocannabinoid system dysregulation from acetaminophen use may lead to autism spectrum disorder: could cannabinoid treatment be efficacious? Paracetamol for low back pain. Toxnet. Drugs & Medications Mentholatum Deep Heat Rub Cream Mentholatum Deep Heat Rub Cream - Uses, Side Effects, Uses This product is used to treat minor aches and pains of the muscles/joints (such as. Call, text, chat, or email for a free personalized risk assessment on exposures in pregnancy and breastfeeding. J. Epidemiol. Teratol. This Consensus Statement is the work of an international group of experts, which included clinicians (specializing in neurology, obstetrics and gynaecology, and paediatrics), epidemiologists and basic scientists (specializing in toxicology, endocrinology, reproductive medicine and neurodevelopment). 31, 26422650 (2016). Prenatal exposure to acetaminophen and risk of ADHD. However, eight out of ten women take at least one prescription or over-the-counter medicine during pregnancy45,46 with APAP being the most common exposure (65%)3,18. Tovo-Rodrigues, L. et al. Our Fact Sheets answer frequently asked questions about many common exposures during pregnancy and breastfeeding, including medications, recreational substances, cosmetic treatments, health conditions, infections, vaccines, and more. Hum. Sci. We here recognize our professional and social responsibility to take this action, even in the face ofuncertainty, in light of the serious consequences of inaction. D.M.K., A.Z.B., D.K., Z.L., S.H.S., R.H.J. Pain. 42, 17021713 (2013). Int. While you might not think that face. In addition to potential effects on neuronal and reproductive development, a combination of clinical studies together with experimental work in animal models and cell lines has also suggested that APAP exposure during pregnancy might decrease fetal haematopoietic stem cell numbers alter steroidogenesis in the placenta and induce placental damage65,77,78,79,80. Present biomarker studies are not without limitations in the assessment of exposure. For example, experimental studies have suggested that APAP can reduce testosterone production in the human fetal testis105. When faced with a seasonal cold or flu while pregnant, you also must consider not only your own health but that of your baby as well when managing your symptoms. Ther. Pro-tip: leave it on for 10 minutes without water, and it doubles as a nourishing mask. There's no . 118, 184189 (2016). Sales of APAP-containing products, which are not restricted to pharmacies in many countries, are increasing worldwide4. MotherToBaby Fact Sheets are listed below by category of exposure. To obtain Aschengrau, A. 7, 149158 (2018). When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. In many of these studies, associations were weak for short-term exposure suggesting that short-term use might be of limited risk. This Beta Hydroxy Acid (BHA) is an excellent exfoliant and can be used to treat acne-prone symptomatic pregnant women. Done and done. Needham, B. D. et al. Gynecol. This is not to suggest that all drugs have a potential for harm. Google Scholar. Human epidemiological studies on APAP should be designed to examine timing, dosage and duration of exposure both prenatally and postnatally. Stergiakouli, E., Thapar, A. AU Exempt: Medications exempted from pregnancy classification are not absolutely safe for use in pregnancy in all circumstances. Markets and Research. In this Consensus Statement, we summarize research showing adverse neurological, urogenital and reproductive outcomes associated with maternal and perinatal use of APAP. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is . Product Information. Cetaphil is known for its to-the-point formula thats pretty much as simple as it gets: Its clear, fragrance-free, gentle, and suitable for just about everyone, including those with sensitive skin. What You Should Know About Taking Mentholatum Deep Heat Rub topical when pregnant, nursing, or administering to children or adults over 60 Skip to main content A-Z Health A-Z Drugs &. Long-term (5 days) fetal exposure resulted in even higher transfer rates than short-term exposure, which might lead to accumulation of APAP in the fetal brain50. fainting. The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Since you first took that positive pregnancy test and estimated Babys arrival on the due date calculator, youve probably been in new mama preparedness mode and begun nesting, planning your baby shower registry (and outfit), shopping for maternity dresses, and thinking about baby names 24/7. For example, present standard targeted methods are based on analysing free APAP and phase II conjugates after enzymatic deconjugation143. Ibuprofen 5% w/w Gel. The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain. Reprod. Hay-Schmidt, A. et al. We may receive a portion of sales from products purchased from this article, which was written by our Commerce team. Am. Quick, easy-to-understand information on 275+ exposures and how they may impact pregnancy or breastfeeding. We recommend the following specific actions to implement the goals of raising awareness amongst patients and health-care providers: The 2015 FDA Drug Safety Communication recommendations should be updated based on evaluation of all available scientific evidence9, including both epidemiological and experimental evidence. Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregnancy. a skin ulcer. Albert, O. et al. Avella-Garcia, C. B. et al. Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. Perception of risk regarding the use of medications and other exposures during pregnancy. Rai-Bhogal, R. et al. Klein, R. M. et al. Complete withdrawal is the most feasible treatment for medication-overuse headache: a randomized controlled open-label trial. Olsen, J. R.T.M. Elective APAP use for the treatment of headache, muscle pain, back pain and infection accounted for APAP use in the majority of women using APAP during pregnancy3,35. J. Epidemiol. D.M.K., A.Z.B., S.H.S. Int. FASEB J. Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study. Horm. 2013;6(5):453-55. doi:10.1586/17512433.2013.827401. Christina S. Han, MD, is a physician who is double board-certified in maternal-fetal medicine and obstetrics and gynecology. An additional study has suggested an association between prenatal APAP exposure and early female puberty93. Google Scholar. Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Nat. Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood. Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging. Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder mediated by frontoparietal network brain connectivity. JAMA Psychiatry 77, 180189 (2020). Clin. ), but this product, which is made in Canada, has a lot going for it! 37, 11741181 (2017). Importantly, the effects of APAP on female development have not yet been properly investigated in human observational studies. J. Epidemiol. Patient Information Leaflet. Research suggests that women are reluctant to use medications during pregnancy23,45. Pharmacol. 45, 19982008 (2016). Skakkebaek, N. E. et al. Jensen, M. S. et al. Moreover, the fact that APAP is a less potent anti-androgen than other pharmaceuticals (for example, ketoconazole) probably means that only large studies would be sufficiently powered to detect effects. Am. APAP exposure assessment relied on maternal self-report in 24 studies, on biomarkers in five studies127,128,129,130,137 and on prescription records in one study138. Most associations for cryptorchidism are seen following long-term APAP exposure (>2 weeks) during late first to early second trimester, which is consistent with the critical time windows for development2,91. Are Cold Medicines Safe During Pregnancy? The People's Pharmacy Is Vicks Dangerous Against Hemorrhoids? 167, 138144 (2019). 168, 2532 (2018). Research suggests that getting a flu vaccination reduces the risk that a woman will be hospitalized for flu-related complications by approximately 40%. Consumer Health Products Association acetaminophen, https://www.marketsandresearch.biz/report/43101/global-acetaminophen-market-2020-by-manufacturers-regions-type-and-application-forecast-to-2026, https://www.ema.europa.eu/en/documents/prac-recommendation/prac-recommendations-signals-adopted-12-15-march-2019-prac-meeting_en.pdf, https://www.acog.org/en/clinical/clinical-guidance/committee-opinion/articles/2021/07/reducing-prenatal-exposure-to-toxic-environmental-agents, https://www.chpa.org/our-issues/otc-medicines/acetaminophen, https://www.knowyourdose.org/the-acetaminophen-awareness-coalition/, http://creativecommons.org/licenses/by/4.0/, Maternal and childhood medical history and the risk of childhood brain tumours: a casecontrol study in Ontario, Canada. Expand All. Toxicol. Low neurodevelopmental performance and behavioural/emotional problems at 24 and 48 months in Brazilian children exposed to acetaminophen during foetal development. A consensus protocol for the management of medication-overuse headache: evaluation in a multicentric, multinational study. Even with frequent use, your skin will still retain its natural moisture. Acetaminophen attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells. APAP is the active ingredient in more than 600 prescription and non-prescription medications used to relieve mild to moderate pain and reduce fever (Consumer Health Products Association acetaminophen). Both reduced AGD and cryptorchidism are indicators of disturbed masculinization and risk factors for reproductive disorders in later life. Briggs, G. and Freeman. Honein, M.; Gilboa, S; and Broussard, C. The need for safer medication use in pregnancy. It has a lot of slip and feels cooling on my face. Med. Two studies also investigated APAP exposure during infancy. Prostaglandins are lipid compounds with physiologically important roles in the development of the gonads in both sexes and the development of the brain57,58,59; therefore, some of the disrupting effects of APAP are probably mediated through this pathway. Lancet Neurol. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. If you breastfeed, avoid applying this medicine to your nipple area. Toxicol. This call to action is consistent with the 2016 Targeting Environmental Neuro-Developmental Risks (TENDR) Consensus Statement47, which we support: We as a society should be able to take protective action when scientific evidence indicates a chemical is of concern, and not wait for unequivocal proof that a chemical is causing harm to our children. Environ. The Acetaminophen Awareness Coalition (Know Your Dose Campaign) should be expanded to include standardized warnings including that pregnant women should forego APAP use unless medically indicated. Ask a doctor or pharmacist if this medicine is safe to use if you have: a cough with mucus; or; a cough caused by smoking, asthma or emphysema. Google Scholar. Reprod. Less serious side effects may be more likely, and you . Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. They state that people should avoid pregnancy if either partner is taking the drug. Fyke, W., Alarcon, J. M., Velinov, M. & Chadman, K. K. Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice. Wilson, H. A., Creighton, C., Scharfman, H., Choleris, E. & MacLusky, N. J. Endocrine insights into the pathophysiology of autism spectrum disorder. De Jonge, C. & Barratt, C. L. R. The present crisis in male reproductive health: an urgent need for a political, social, and research roadmap. Gynecol. Two notable studies overcame some of the important limitations of earlier studies. Paediatr. Int. The reference lists of identified papers were then searched for additional relevant articles. Grandjean, P. & Landrigan, P. J. Neurobehavioural effects of developmental toxicity. APAP is a modifiable exposure. Liew, Z., Ritz, B., Virk, J., Arah, O. Med. Eur. E-V-E-R-Y-T-H-I-N-G. Res. FASEB J. Another alarming reminder came with the news that champion U.S. sprinter . -If used on the nipples, use after nursing and wipe off before the next nursing. Pharmacol. 112, 943952 (2020). APAP is known to readily cross the placenta and bloodbrain barrier49,50. Burman, A. et al. Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study, Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments, Handle with care interpretation, synthesis and dissemination of data on paracetamol in pregnancy, Caution needed: paracetamol use in pregnancy, Paracetamol use in pregnancy caution over causal inference from available data, Reply to Paracetamol use in pregnancy caution over causal inference from available data; Handle with care interpretation, synthesis and dissemination of data on paracetamol in pregnancy, Paracetamol use in pregnancy neglecting context promotes misinterpretation, Reply to Paracetamol use in pregnancy neglecting context promotes misinterpretation, Sign up for Nature Briefing: Translational Research. Bisson, D., Newell, S. & Laxton, C. on behalf of the Royal College of Obstetricians and Gynaecologists. Some other products are only safe to take at certain points of fetal development. Epidemiol. Update 27, 6795 (2021). Arch. Hum. Even if you're a conscious beauty user and you've nixed the most offensive, toxic ingredients, strange things are happening to your skin now that you're pregnant (same with your hair, your vision you get it). & Chang, J. PubMed Dreier, J. W., Andersen, A.-M. N. & Berg-Beckhoff, G. Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring. 9, 951958 (2016). La Merrill, M. A. et al. Data support the contribution of environmental exposure during fetal life, including exposure to pharmaceuticals, to these increases in rates of neurological, urogenital and reproductive disorders13,14. https://www.fda.gov/media/90209/download (2015). This is one of those situations where sometimes, less is more. 66, 207214 (2010). PubMed Fetal APAP exposure has been demonstrated to induce changes in neurotransmission in the brain manifesting in altered cognitive function, behaviour and locomotion. Paracetamol medication during pregnancy: insights on intake frequencies, dosages and effects on hematopoietic stem cell populations in cord blood from a longitudinal prospective pregnancy cohort. Consumers should look for the EWG VERIFIED logo, which indicates that the company has fully vetted ingredients for safety.. Talk with your doctor about whether it's safe to have sex while you're pregnant. The Food and Drug Administration (FDA) does not approve the use of methotrexate during pregnancy. Independently of APAP, these processes have been implicated as mechanisms related to the development of neurodevelopmental66,67,68,69,70,71,72,73,74,75,76 and reproductive disorders2. If you are outside for . Antioxidants might affect radiation treatment. Pediatr. If you discover you are pregnant soon after taking a cold medicine, most likely there will be no adverse effects. Toxicol. For example, the US National Health Interview Survey reported that between 2009 and 2017, approximately one in six children aged 317 years had a developmental disability diagnosis. Occup. Gynecol. Tronnes, J. N., Wood, M., Lupattelli, A., Ystrom, E. & Nordeng, H. Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children. Psychiatry 26, 6669 (2021). 294, 95104 (2018). Many new moms experience a period of feeling down or anxious, sometimes called the baby blues. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. 18, 1425 (2017). I highly recommend this product.. Prenatal APAP exposure has also been associated with earlier female pubertal development. Sci Immunol. 408, 113294 (2021). Four independent research teams have found consistently that prenatal APAP exposure can reduce female reproductive health and fertility81,87,88,106,108,109. J. Clin. 124, A118A122 (2016). Plasma and fecal metabolite profiles in autism spectrum disorder. Pain. This period is when male reproductive development (including AGD) is considered to be programmed91,100. In these cohorts exposure information was collected in a timely manner to attempt to minimize exposure misclassification and recall bias. I love all the products but the cleanser is really something special. Arendrup, F. S., Mazaud-Guittot, S., Jegou, B. severe burning, stinging, or irritation after using this medicine; or. If you havent tried their Healthy Living App yet, you scan your product and find out what is good (or not so good) about it. Fetal exposure in animal models has been shown experimentally to cause disorders of the male urogenital tract through reduction of androgen action2. Des. Liew, Z., Ritz, B., Virk, J. 1. Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated? Collectively, the studies suggest that the timing and duration of maternal APAP use are critical factors. Approved by dermatologists, Amazon customers cant get enough of this product, with one happy reviewer stating that this cleanser does not irritate our skin AND our faces are clean. 62, 10851091 (2015). What to Do If Your Baby Wont Stop Coughing, 10 Things You Can Do Right Now to Reduce Your Risk of Pregnancy Loss, Fever in pregnancy and the risk of congenital malformations: a cohort study, Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy: a multi-country retrospective test negative design study, 2010-2016, The need for safer medication use in pregnancy, Expectorants containing guaifenesin to help clear mucus, Alcohol-free cough syrups containing dextromethorphan, such as Tussin DM, Combination guaifenesin/dextromethorphan drugs. Consistent with the epidemiological data, studies have demonstrated that the strongest effects of long-term use and exposure occur at a time equivalent to the beginning of the third trimester of pregnancy and the time around birth in humans69,148. An immune clock of human pregnancy. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT 2013. Flu and pregnant women. 185, 28052818 (2015). Over-the-counter cough drops don't contain pure menthol. Fundam. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Side Effects Dosage Drug Interactions Pregnancy & Breastfeeding What Else to Know Generic Name: methyl salicylate and menthol Brand Names: Bengay, Icy Hot, Mentholatum D, Salonpas Drug Class: Analgesics, Topical What is methyl salicylate/menthol, and what is it used for? Rarely, inhaling petroleum jelly for prolonged periods can cause lung inflammation (lipoid pneumonia). Paracetamol effect of early exposure on neurotransmission, spatial memory and motor performance in rats. 12, 125136 (2020). 138, 139147 (2014). Addo, K. A., Palakodety, N. & Fry, R. C. Acetaminophen modulates the expression of steroidogenesis-associated genes and estradiol levels in human placental JEG-3 cells. Cleans deeply and leaves fave feeling nourished, not dry. Eur. 45, 528533 (2017). Holm, J. Every woman deserves to thrive. It is made by a company known as Mentholatum. Physiologically based pharmacokinetic modeling to characterize acetaminophen pharmacokinetics and N-acetyl-p-benzoquinone imine (NAPQI) formation in non-pregnant and pregnant women.